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Article

Regulation of Notch1 Gene Expression by p53 in Epithelial Cells

13 Mar 2007

Abstract excerpt

The E6 protein of cervical cancer-associated human papillomaviruses (HPVs) is known to suppress keratinocyte differentiation through unidentified mechanisms. Notch1 is a determinant of keratinocyte differentiation and functions as a tumor suppressor in mammalian epidermis. Here, we report that the Notch1 gene is a novel target of p53 and can be down-regulated by E6 through p53 degradation in normal human...

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PMID: 17353266
DOI: 10.1128/mcb.02119-06

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Regulation of Notch1 Gene Expression by p53 in Epithelial CellsPMID 17353266Read ↗

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