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Article

Activity of human papillomavirus type 16 P97 promoter in immortal and tumorigenic human oral keratinocytes.

International journal of oncology - 1 Oct 1998

Kook J K, Kim J H, Min B M

Abstract excerpt

We previously immortalized normal human oral keratinocytes (NHOK) by transfection with cloned human papillomavirus type 16 (HPV-16) genome and converted these immortalized cells to tumorigenic cells with chemical carcinogens. Since the tumorigenic cells expressed higher level of HPV-16 E6/E7 transcripts, we predicted that enhanced E6/E7 expression was induced by mutations at the long control region (LCR) of the...

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Identifiers

PMID: 9735407
DOI: 10.3892/ijo.13.4.765

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activity of human papillomavirus type 16 P97 promoter in immortal and tumorigenic human oral keratinocytes.PMID 9735407Read ↗

The viral transcriptional regulatory region upstream of the E6 and E7 genes is a major determinant of the differential immortalization activities of human papillomavirus types 16 and 18Semantic proximity Read ↗

An AP-1 binding site mutation in HPV-16 LCR enhances E6/E7 promoter activity in human oral epithelial cells.Semantic proximity Read ↗

Sequence analysis of the long control region of human papillomavirus type 16 variants and functional consequences for P97 promoter activitySemantic proximity Read ↗

Disruption of either the E1 or the E2 regulatory gene of human papillomavirus type 16 increases viral immortalization capacity.Semantic proximity Read ↗

Immortalization of oral keratinocytes by functional inactivation of the p53 and pRb pathways.Semantic proximity Read ↗

The E8 Domain Confers a Novel Long-Distance Transcriptional Repression Activity on the E8^E2C Protein of High-Risk Human Papillomavirus Type 31Semantic proximity Read ↗

Differences in transformation activity between HPV-18 and HPV-16 map to the viral LCR-E6-E7 regionSemantic proximity Read ↗

Immortalization of normal human oral keratinocytes with type 16 human papillomavirusSemantic proximity Read ↗

DNA polymerase β promoter mutations and transcriptional activity in esophageal squamous cell carcinoma.Semantic proximity Read ↗

Mutational analysis of cis elements involved in E2 modulation of human papillomavirus type 16 P97 and type 18 P105 promoters.Semantic proximity Read ↗

The E8 <sup>∧</sup> E2 Gene Product of Human Papillomavirus Type 16 Represses Early Transcription and Replication but Is Dispensable for Viral Plasmid Persistence in KeratinocytesSemantic proximity Read ↗

The E8E2C protein, a negative regulator of viral transcription and replication, is required for extrachromosomal maintenance of human papillomavirus type 31 in keratinocytes.Semantic proximity Read ↗

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