Mechanisms of decreased expression of transforming growth factor-beta receptor type I at late stages of HPV16-mediated transformation.

doi:10.1016/j.canlet.2009.03.014

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Article

Mechanisms of decreased expression of transforming growth factor-beta receptor type I at late stages of HPV16-mediated transformation.

Cancer letters - 18 Sept 2009

Hypes Melissa K, Pirisi Lucia, Creek Kim E

Abstract excerpt

Transforming growth factor-beta (TGF-beta) signaling is disrupted in many cancers, including cervical cancer, leading to TGF-beta resistance. Although initially sensitive, human papillomavirus type 16 (HPV16) immortalized human keratinocytes (HKc/HPV16) become increasingly resistant to the growth inhibitory effects of TGF-beta during in vitro progression to a differentiation resistant phenotype (HKc/DR). We have...

Topics

Binding Sites
Cell Transformation, Neoplastic
Cells, Cultured
DNA Methylation
Electrophoretic Mobility Shift Assay
Human papillomavirus 16
Humans
Mutation
Oncogene Proteins, Viral
Papillomavirus E7 Proteins
Promoter Regions, Genetic
Protein Serine-Threonine Kinases
RNA, Messenger

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptor, Transforming Growth Factor-beta Type I

Receptor, Transforming Growth Factor-beta Type II

Receptors, Transforming Growth Factor beta

Repressor Proteins

Sp1 Transcription Factor

Source

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Identifiers

PMID: 19344999
DOI: 10.1016/j.canlet.2009.03.014
PMCID: PMC2710415

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