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Article

WT1-Mediated Gene Regulation in Early Urogenital Ridge Development

1 Jan 2007

Abstract excerpt

The Wilms tumor protein WT1 is involved in the development of several organs, including the gonads. WT1 mutations in humans lead to syndromes associated with impaired sexual development and Wt1 knockout mice show regression of gonad anlagen. As a transcription factor, WT1 fulfills its function by regulating a set of target genes. With respect to gonad development only few in vivo WT1 targets, e.g. steroidogenic...

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PMID: 18391535
DOI: 10.1159/000104774

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