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The Wilms’ Tumor Suppressor Gene (<i>wt1</i>) Product Regulates <i>Dax-1</i> Gene Expression during Gonadal Differentiation

1 Mar 1999

Abstract excerpt

Gonadal differentiation is dependent upon a molecular cascade responsible for ovarian or testicular development from the bipotential gonadal ridge. Genetic analysis has implicated a number of gene products essential for this process, which include Sry, WT1, SF-1, and DAX-1. We have sought to better define the role of WT1 in this process by identifying downstream targets of WT1 during normal gonadal development....

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PMID: 10022915
DOI: 10.1128/mcb.19.3.2289

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