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Exploring the Multifaceted Role of WT1 in Kidney Development and Disease

10 Feb 2025

Abstract excerpt

BACKGROUND: The Wilms' tumor suppressor gene (WT1) is a critical regulator in kidney development and disease pathogenesis. With the identification of at least 36 isoforms in mammals, each potentially playing distinct roles, WT1's complexity is becoming increasingly apparent. The -KTS and +KTS isoforms, in particular, have been implicated in DNA and RNA regulation, respectively. This review consolidates recent...

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PMID: 39929160
DOI: 10.1159/000544025

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