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Article

WT-1 is required for early kidney development.

Cell - 27 Aug 1993

Kreidberg J A, Sariola H, Loring J M, Maeda M, Pelletier J, Housman D, Jaenisch R

Abstract excerpt

In humans, germline mutations of the WT-1 tumor suppressor gene are associated with both Wilms' tumors and urogenital malformations. To develop a model system for the molecular analysis of urogenital development, we introduced a mutation into the murine WT-1 tumor suppressor gene by gene targetin...

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PMID: 8395349
DOI: 10.1016/0092-8674(93)90515-r

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-8395349-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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