Article
WT-1 is required for early kidney development.
Cell - 27 Aug 1993
Kreidberg J A, Sariola H, Loring J M, Maeda M, Pelletier J, Housman D, Jaenisch R
Abstract excerpt
In humans, germline mutations of the WT-1 tumor suppressor gene are associated with both Wilms' tumors and urogenital malformations. To develop a model system for the molecular analysis of urogenital development, we introduced a mutation into the murine WT-1 tumor suppressor gene by gene targeting in embryonic stem cells. The mutation resulted in embryonic lethality in homozygotes, and examination of mutant...
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