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Article

Functional characterization of a novel polymorphism of pregnane X receptor, Q158K, in Chinese subjects.

Pharmacogenetics and genomics - 1 May 2005

Lim Yun-Ping, Liu Chin-Hung, Shyu Lih-Jen, Huang Jin-Ding

Abstract excerpt

The pregnane X receptor (PXR) is the main transcriptional regulator of many enzymes that metabolize xenobiotics such as P450s and drug transporters. Polymorphisms in the PXR gene contribute to population variability in CYP3A4 and P-glycoprotein levels. Single nucleotide polymorphisms (SNPs) have been reported in Caucasian, African-American and Japanese populations. In the present study, we identified the known...

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Identifiers

PMID: 15864135
DOI: 10.1097/01213011-200505000-00009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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