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Article

Screening for polymorphisms in the PXR gene in a Dutch population.

European journal of clinical pharmacology - 1 May 2006

Bosch Tessa M, Deenen Maarten, Pruntel Roelof, Smits Paul H M, Schellens Jan H M, Beijnen Jos H, Meijerman Irma

Abstract excerpt

OBJECTIVE: Cytochrome P450 3A4 (CYP3A4) is involved in the metabolism of over 50% of all drugs currently in use. However, CYP3A4 expression shows a large inter-individual variation that cannot only be explained by genetic polymorphisms identified in this gene. The pregnane X receptor (PXR) has been identified as a transcriptional regulator of CYP3A4. Single nucleotide polymorphisms (SNPs) in the PXR gene could...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16568343
DOI: 10.1007/s00228-006-0108-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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