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Article

Identification of Saccharomyces cerevisiae Tub1 alpha-tubulin as a potential target for NKH-7, a cytotoxic 1-naphthol derivative compound.

Bioscience, biotechnology, and biochemistry - 1 Apr 2008

Chanklan Ruthada, Mizunuma Masaki, Kongkathip Ngampong, Hasitapan Komkrit, Kongkathip Boonsong, Miyakawa Tokichi

Abstract excerpt

In a screening for small-molecule compounds that alleviate the deleterious effects of external CaCl(2) on zds1 Delta strain yeast, we found 2-((1-(hydroxymethyl) cyclohexyl) methyl) naphthalen-1-ol (NKH-7) to be an active compound. NKH-7 also inhibited cell growth at higher concentrations. To identify its target in growth inhibition, we isolated NKH-7-resistant mutants and selected those mutants that exhibited...

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Identifiers

PMID: 18391444
DOI: 10.1271/bbb.70775

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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