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Article

Hybrid alphavirus–rhabdovirus propagating replicon particles are versatile and potent vaccine vectors

7 Apr 2008

Abstract excerpt

Self-propagating, infectious, virus-like particles are generated in animal cell lines transfected with a Semliki Forest virus RNA replicon encoding a single viral structural protein, the vesicular stomatitis virus (VSV) glycoprotein. We show here that these infectious particles, which we call propagating replicons, are potent inducers of neutralizing antibody in animals yet are nonpathogenic. Mice vaccinated with...

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PMID: 18391206
DOI: 10.1073/pnas.0800280105

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