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Replicon RNA Viral Vectors as Vaccines

7 Nov 2016

Abstract excerpt

Single-stranded RNA viruses of both positive and negative polarity have been used as vectors for vaccine development. In this context, alphaviruses, flaviviruses, measles virus and rhabdoviruses have been engineered for expression of surface protein genes and antigens. Administration of replicon RNA vectors has resulted in strong immune responses and generation of neutralizing antibodies in various animal models....

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PMID: 27827980
DOI: 10.3390/vaccines4040039

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