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Self-Replicating Alphaviruses: From Pathogens to Therapeutic Agents

12 Nov 2024

Abstract excerpt

Alphaviruses are known for being model viruses for studying cellular functions related to viral infections but also for causing epidemics in different parts of the world. More recently, alphavirus-based expression systems have demonstrated efficacy as vaccines against infectious diseases and as therapeutic applications for different cancers. Point mutations in the non-structural alphaviral replicase genes have...

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PMID: 39599876
DOI: 10.3390/v16111762

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