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Article

Self-Replicating RNA Viruses for RNA Therapeutics

13 Dec 2018

Abstract excerpt

Self-replicating single-stranded RNA viruses such as alphaviruses, flaviviruses, measles viruses, and rhabdoviruses provide efficient delivery and high-level expression of therapeutic genes due to their high capacity of RNA replication. This has contributed to novel approaches for therapeutic applications including vaccine development and gene therapy-based immunotherapy. Numerous studies in animal tumor models...

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PMID: 30551668
DOI: 10.3390/molecules23123310

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