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Therapeutic and prophylactic applications of alphavirus vectors

1 Nov 2008

Abstract excerpt

Alphavirus vectors are high-level, transient expression vectors for therapeutic and prophylactic use. These positive-stranded RNA vectors, derived from Semliki Forest virus, Sindbis virus and Venezuelan equine encephalitis virus, multiply and are expressed in the cytoplasm of most vertebrate cells, including human cells. Part of the genome encoding the structural protein genes, which is amplified during a normal...

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PMID: 19000329
DOI: 10.1017/s1462399408000859

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