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Article

Estimating the contribution of genes and environment to variation in renal drug clearance.

Pharmacogenetics - 1 Sept 2003

Leabman Maya K, Giacomini Kathleen M

Abstract excerpt

Renal excretion is the major pathway for elimination of many clinically used drugs and xenobiotics. We estimated the genetic component (rGC) contributing to variation in renal clearance for six compounds (amoxicillin, ampicillin, metformin, terodiline, digoxin and iohexol) using Repeated Drug Application methodology. Data were obtained from published literature. The rGC values of renal clearance of metformin,...

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Identifiers

PMID: 12972957
DOI: 10.1097/00008571-200309000-00007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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