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Article

Formation of the double helix: a mutational study.

Nucleic acids research - 1 May 2008

Majlessi Mehrdad, Becker Michael M

Abstract excerpt

To investigate the mechanisms by which oligonucleotides hybridize to target molecules, the binding of two oligodeoxynucleotide probes to RNA targets was measured over a broad range of temperatures. Mutations were then scanned across each DNA/RNA hybrid to map, at single base resolution, sequences important for hybridization. Despite being unrelated in sequence, each hybrid formed by a similar mechanism. In the...

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Identifiers

PMID: 18388130
DOI: 10.1093/nar/gkn134
PMCID: PMC2396424

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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