Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protein kinase A-induced phosphorylation of the p65 subunit of nuclear factor-kappaB promotes Schwann cell differentiation into a myelinating phenotype.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 2 Apr 2008

Yoon Choya, Korade Zeljka, Carter Bruce D

Abstract excerpt

Axon-Schwann cell interactions are critical for myelin formation during peripheral nerve development and regeneration. Axonal contact promotes Schwann cell precursors to differentiate into a myelinating phenotype, and cAMP-elevating agents can mimic this; however, the mechanisms underlying this differentiation are poorly understood. We demonstrated previously that the transcription factor nuclear factor-kappaB...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Coculture Techniques
Share to Cyclic AMP-Dependent Protein Kinases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Electrophoretic Mobility Shift Assay

Share to Ganglia, Spinal

Share to Myelin Sheath

Share to Schwann Cells

Share to Sciatic Nerve

Share to Transcription Factor RelA

Source

Open in PubMed Open full text

Identifiers

PMID: 18385332
DOI: 10.1523/JNEUROSCI.4439-07.2008
PMCID: PMC6671072

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protein kinase A-induced phosphorylation of the p65 subunit of nuclear factor-kappaB promotes Schwann cell differentiation into a myelinating phenotype.PMID 18385332Read ↗

Activation of the transcription factor NF-kappaB in Schwann cells is required for peripheral myelin formation.Semantic proximity Read ↗

Analysis of Gpr126 function defines distinct mechanisms controlling the initiation and maturation of myelin.Semantic proximity Read ↗

A G protein-coupled receptor is essential for Schwann cells to initiate myelination.Semantic proximity Read ↗

Gene-targeted deletion of neurofibromin enhances the expression of a transient outward K+ current in Schwann cells: a protein kinase A-mediated mechanism.Semantic proximity Read ↗

Modulation of the neurofibromatosis type 1 gene product, neurofibromin, during Schwann cell differentiation.Semantic proximity Read ↗

A cAMP-activated pathway, including PKA and PI3K, regulates neuronal differentiationSemantic proximity Read ↗

Non-antagonistic relationship between mitogenic factors and cAMP in adult Schwann cell re-differentiation.Semantic proximity Read ↗

Cyclic AMP-induced neuronal differentiation via activation of p38 mitogen-activated protein kinase.Semantic proximity Read ↗

Modulation of Schwann cell phenotype by TGF-beta 1: inhibition of P0 mRNA expression and downregulation of the low affinity NGF receptor.Semantic proximity Read ↗

Transforming growth factor-beta 1 and forskolin modulate gap junctional communication and cellular phenotype of cultured Schwann cells.Semantic proximity Read ↗

Elevated intracellular levels of cAMP induce olfactory ensheathing cells to express GAL-C and GFAP but not MBP.Semantic proximity Read ↗

Sustained activation of phosphatidylinositol 3-kinase/Akt/nuclear factor kappaB signaling mediates G protein-coupled delta-opioid receptor gene expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.