Article
Gene-targeted deletion of neurofibromin enhances the expression of a transient outward K+ current in Schwann cells: a protein kinase A-mediated mechanism.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Nov 2002
Xu Yanfang, Chiamvimonvat Nipavan, Vázquez Ana E, Akunuru Shailaja, Ratner Nancy, Yamoah Ebenezer N
Abstract excerpt
Mutations in the neurofibromatosis type 1 gene predispose patients to develop benign peripheral nerve tumors (neurofibromas) containing Schwann cells (SCs). SCs from neurofibromatosis type-1 gene (Nf1) null mutant mice showed increased levels of Ras-GTP and cAMP. The proliferation and differentiation of SCs are regulated by Ras-GTP and cAMP-mediated signaling, which have been linked to expression of K+ channels....
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