Article
Modulation of Schwann cell phenotype by TGF-beta 1: inhibition of P0 mRNA expression and downregulation of the low affinity NGF receptor.
Glia - 1 Jul 1993
Mews M, Meyer M
Abstract excerpt
The phenotype of a fully differentiated, mature Schwann cell is apparently largely determined by Schwann cell-axon interactions. In vitro, elevation of intracellular cAMP levels in Schwann cells induces a phenotype which resembles that of a mature, i.e., axon-related, Schwann cell. Therefore, an...
Topics
- Animals
- Biomarkers
- Blotting, Northern
- Cells, Cultured
- Colforsin
- Cyclic AMP
- Down-Regulation
- Drug Synergism
- Gene Expression Regulation
- Myelin P0 Protein
- Myelin Proteins
- Myelin Sheath
- Nerve Tissue Proteins
- Phenotype
- RNA, Messenger
- Rats
- Rats, Wistar
- Receptors, Nerve Growth Factor