Article
Epigenetic regulation identifies RASEF as a tumor-suppressor gene in uveal melanoma.
Investigative ophthalmology & visual science - 1 Apr 2008
Maat Willem, Beiboer Sigrid H W, Jager Martine J, Luyten Gré P M, Gruis Nelleke A, van der Velden Pieter A
Abstract excerpt
PURPOSE: Recently, a segregation study in families with uveal and cutaneous melanoma identified 9q21 as a potential locus harboring a tumor-suppressor gene (TSG). One of the genes in this area, RASEF, was then analyzed as a candidate TSG, but lack of point mutations and copy number changes could not confirm this. In this study, the RASEF gene was investigated for potential mutations and gene silencing by promoter...
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