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The role of RASSF1A in uveal melanoma.

Investigative ophthalmology & visual science - 3 Oct 2012

Dratviman-Storobinsky Olga, Cohen Yoram, Frenkel Shahar, Merhavi-Shoham Efrat, El Shimrit Dadon-Bar, Binkovsky Natalia, Pe'er Jacob, Goldenberg-Cohen Nitza

Abstract excerpt

PURPOSE: RASSF1A inactivation in uveal melanoma (UM) is common and methylation-induced. We investigated the effect of RASSF1A re-expression on the UM phenotype in vivo and in vitro. METHODS: The phenotypic effect of methylation-induced inactivation of RASSF1A in UM was explored using a stable RASSF1A-expressing UM-15 clone. RASSF1A expression was assessed using QRT-PCR. Proliferation was evaluated in vitro using...

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PMID: 22447862
DOI: 10.1167/iovs.11-7730

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