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EFS shows biallelic methylation in uveal melanoma with poor prognosis as well as tissue-specific methylation

26 Aug 2011

Abstract excerpt

BACKGROUND: Uveal melanoma (UM) is a rare eye tumor. There are two classes of UM, which can be discriminated by the chromosome 3 status or global mRNA expression profile. Metastatic progression is predominantly originated from class II tumors or from tumors showing loss of an entire chromosome 3 (monosomy 3). We performed detailed EFS (embryonal Fyn-associated substrate) methylation analyses in UM, cultured uveal...

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PMID: 21871071
DOI: 10.1186/1471-2407-11-380

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