Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Methylation of CpG island promoters in uveal melanoma.

The British journal of ophthalmology - 1 Feb 2008

Moulin A P, Clément G, Bosman F T, Zografos L, Benhattar J

Abstract excerpt

BACKGROUND: Inactivation of tumour-related genes by promoter hypermethylation is a common epigenetic event in the development of a variety of tumours. AIM: To investigate in primary uveal melanoma the status of promoter methylation of genes thought to be involved in tumour development: p16, TIMP3, RASSF1, RARB, FHIT, hTERT and APC. METHODS: Gene promoter methylation was studied by methylation-sensitive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Melanoma
Share to Genes, Neoplasm
Share to CpG Islands

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Methylation

Share to DNA, Neoplasm

Share to Epigenesis, Genetic

Share to Promoter Regions, Genetic

Share to Uveal Neoplasms

Source

Identifiers

PMID: 18211945
DOI: 10.1136/bjo.2007.127035

Genes

APC
FHIT
RARB
RASSF1
TIMP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Methylation of CpG island promoters in uveal melanoma.PMID 18211945Read ↗

Promoter methylation status of multiple genes in uveal melanoma.Semantic proximity Read ↗

Epigenetic Inactivation of RASSF1a in Uveal MelanomaSemantic proximity Read ↗

Mutational analysis of selected genes in the TGFbeta, Wnt, pRb, and p53 pathways in primary uveal melanoma.Semantic proximity Read ↗

Aberrant DNA methylation is associated with aggressive clinicopathological features and poor survival in cutaneous melanoma.Semantic proximity Read ↗

Epigenetic regulation identifies RASEF as a tumor-suppressor gene in uveal melanoma.Semantic proximity Read ↗

The role of RASSF1A in uveal melanoma.Semantic proximity Read ↗

Clinical implications of promoter hypermethylation in RASSF1A and MGMT in retinoblastoma.Semantic proximity Read ↗

Azacytidine treatment affects the methylation pattern of genomic and cell-free DNA in uveal melanoma cell linesSemantic proximity Read ↗

Azacytidine Treatment Affects Methylation Pattern of Genomic and Cell-Free DNA in Uveal Melanoma Cell LinesSemantic proximity Read ↗

Low frequency of p16/CDKN2A methylation in sporadic melanoma: comparative approaches for methylation analysis of primary tumors.Semantic proximity Read ↗

Methylation analysis of several tumour suppressor genes shows a low frequency of methylation of CDKN2A and RARB in uveal melanomas.Semantic proximity Read ↗

Hypermethylation of CpG island loci of multiple tumor suppressor genes in retinoblastoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.