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Microphthalmia-Associated Transcription Factor: A Differentiation Marker in Uveal Melanoma

16 May 2023

Abstract excerpt

Microphthalmia-associated transcription factor (MITF) is an important regulator of melanogenesis and melanocyte development. In cutaneous melanoma, MITF loss has been linked to an increased expression of stem cell markers, a shift in epithelial-to-mesenchymal transition (EMT)-related factors, and increased inflammation. We explored the role of MITF in Uveal Melanoma (UM) using a cohort of 64 patients enucleated...

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PMID: 37240204
DOI: 10.3390/ijms24108861

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