Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation of mutant TERT promoter by RAS-ERK signaling is a key step in malignant progression of BRAF-mutant human melanomas.

Proceedings of the National Academy of Sciences of the United States of America - 13 Dec 2016

Li Yinghui, Cheng Hui Shan, Chng Wee Joo, Tergaonkar Vinay

Abstract excerpt

Although activating BRAF/NRAS mutations are frequently seen in melanomas, they are not sufficient to drive malignant transformation and require additional events. Frequent co-occurrence of mutations in the promoter for telomerase reverse transcriptase (TERT), along with BRAF alterations, has recently been noted and correlated with poorer prognosis, implicating a functional link between BRAF signaling and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Imidazoles
Share to MAP Kinase Signaling System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oximes

Share to Pyridones

Share to Pyrimidinones

Share to ras Proteins

Share to RNA Polymerase II

Share to Telomerase

Source

Open in PubMed Open full text

Identifiers

PMID: 27911794
DOI: 10.1073/pnas.1611106113
PMCID: PMC5167176

Genes

BRAF
TERT
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of mutant TERT promoter by RAS-ERK signaling is a key step in malignant progression of BRAF-mutant human melanomas.PMID 27911794Read ↗

TERT promoter mutations in melanoma render TERT expression dependent on MAPK pathway activation.Semantic proximity Read ↗

TERT Promoter Mutations and Telomerase in MelanomaSemantic proximity Read ↗

TERT Expression Induces Resistance to BRAF and MEK Inhibitors in BRAF-Mutated Melanoma In VitroSemantic proximity Read ↗

TERT promoter mutations in cancer development.Semantic proximity Read ↗

Mechanisms of TERT Reactivation and Its Interaction with BRAFV600E.Semantic proximity Read ↗

TERT promoter mutations are frequent in cutaneous basal cell carcinoma and squamous cell carcinoma.Semantic proximity Read ↗

TERT promoter mutations are frequent in atypical fibroxanthomas and pleomorphic dermal sarcomas.Semantic proximity Read ↗

Mutations in the promoter of the telomerase gene TERT contribute to tumorigenesis by a two-step mechanism.Semantic proximity Read ↗

Highly recurrent TERT promoter mutations in human melanoma.Semantic proximity Read ↗

TERT promoter mutations in familial and sporadic melanoma.Semantic proximity Read ↗

Reactivation of telomerase reverse transcriptase expression in cancer: the role of TERT promoter mutationsSemantic proximity Read ↗

Interplay between TERT promoter mutations and methylation culminates in chromatin accessibility and TERT expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.