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Article

SRSF2 Mutations in Uveal Melanoma: A Preference for In-Frame Deletions?

17 Aug 2019

Abstract excerpt

Background: Uveal melanoma (UM) is the most common primary ocular malignancy in adults in the Western world. UM with a mutation in SF3B1, a spliceosome gene, is characterized by three or more structural changes of chromosome 1, 6, 8, 9, or 11. Also UM without a mutation in SF3B1 harbors similar chromosomal aberrations. Since, in addition to SF3B1, mutations in U2AF1 and SRSF2 have also been observed in...

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PMID: 31426461
DOI: 10.3390/cancers11081200

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