Article
Mapping of a novel ocular and cutaneous malignant melanoma susceptibility locus to chromosome 9q21.32.
Journal of the National Cancer Institute - 21 Sept 2005
Jönsson Göran, Bendahl Pär-Ola, Sandberg Therese, Kurbasic Azra, Staaf Johan, Sunde Lone, Crüger Dorthe G, Ingvar Christian, Olsson Håkan, Borg Ake
Abstract excerpt
An estimated 10% of all cutaneous malignant melanoma (CMM) cases are inherited, but the genetics of familial CMM are largely unknown. Ocular malignant melanoma (OMM), which is rare, may be associated with familial CMM. We performed a genome-wide scan of two Danish pedigrees with multiple cases of OMM (N = 10) and CMM (N = 3) and other malignancies (with no germline mutations in CDKN2A, CDK4, BRCA1, and BRCA2) to...
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