Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pro-protein convertases control the maturation and processing of the iron-regulatory protein, RGMc/hemojuvelin.

BMC biochemistry - 2 Apr 2008

Kuninger David, Kuns-Hashimoto Robin, Nili Mahta, Rotwein Peter

Abstract excerpt

BACKGROUND: Repulsive guidance molecule c (RGMc or hemojuvelin), a glycosylphosphatidylinositol-linked glycoprotein expressed in liver and striated muscle, plays a central role in systemic iron balance. Inactivating mutations in the RGMc gene cause juvenile hemochromatosis (JH), a rapidly progressing iron storage disorder with severe systemic manifestations. RGMc undergoes complex biosynthetic steps leading to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Furin
Share to GPI-Linked Proteins
Share to Hemochromatosis Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Weight

Share to Muscle Proteins

Share to Proprotein Convertases

Share to Protein Processing, Post-Translational

Source

Open in PubMed Open full text

Identifiers

PMID: 18384687
DOI: 10.1186/1471-2091-9-9
PMCID: PMC2323002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pro-protein convertases control the maturation and processing of the iron-regulatory protein, RGMc/hemojuvelin.PMID 18384687Read ↗

Complex biosynthesis of the muscle-enriched iron regulator RGMc.Semantic proximity Read ↗

Selective binding of RGMc/hemojuvelin, a key protein in systemic iron metabolism, to BMP-2 and neogenin.Semantic proximity Read ↗

Soluble repulsive guidance molecule c/hemojuvelin is a broad spectrum bone morphogenetic protein (BMP) antagonist and inhibits both BMP2- and BMP6-mediated signaling and gene expression.Semantic proximity Read ↗

Defective targeting of hemojuvelin to plasma membrane is a common pathogenetic mechanism in juvenile hemochromatosisSemantic proximity Read ↗

Hemojuvelin N-terminal mutants reach the plasma membrane but do not activate the hepcidin response.Semantic proximity Read ↗

Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overloadSemantic proximity Read ↗

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression.Semantic proximity Read ↗

Expression of Rgmc, the murine ortholog of hemojuvelin gene, is modulated by development and inflammation, but not by iron status or erythropoietinSemantic proximity Read ↗

Immunoassay for human serum hemojuvelin.Semantic proximity Read ↗

HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis.Semantic proximity Read ↗

Neogenin-mediated hemojuvelin shedding occurs after hemojuvelin traffics to the plasma membrane.Semantic proximity Read ↗

Identification of furin pro-region determinants involved in folding and activation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.