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Article

Neogenin-mediated hemojuvelin shedding occurs after hemojuvelin traffics to the plasma membrane.

The Journal of biological chemistry - 20 Jun 2008

Zhang An-Sheng, Yang Fan, Meyer Kathrin, Hernandez Catalina, Chapman-Arvedson Tara, Bjorkman Pamela J, Enns Caroline A

Abstract excerpt

HFE2 (hemochromatosis type 2 gene) is highly expressed in skeletal muscle and liver hepatocytes. Its encoded protein, hemojuvelin (HJV), is a co-receptor for the bone morphogenetic proteins 2 and 4 (BMP2 and BMP4) and enhances the BMP-induced hepcidin expression. Hepcidin is a central iron regula...

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Source

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Identifiers

PMID: 18445598
DOI: 10.1074/jbc.M710527200
PMCID: PMC2427329

Genes

HJV
BMP2
BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18445598-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neogenin-mediated hemojuvelin shedding occurs after hemojuvelin traffics to the plasma membrane.PMID 18445598Read ↗

Neogenin Facilitates the Induction of Hepcidin Expression by Hemojuvelin in the Liver.Semantic proximity Read ↗

Hemojuvelin N-terminal mutants reach the plasma membrane but do not activate the hepcidin response.Semantic proximity Read ↗

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression.Semantic proximity Read ↗

Defective targeting of hemojuvelin to plasma membrane is a common pathogenetic mechanism in juvenile hemochromatosisSemantic proximity Read ↗

Matriptase-2- and proprotein convertase-cleaved forms of hemojuvelin have different roles in the down-regulation of hepcidin expression.Semantic proximity Read ↗

Selective binding of RGMc/hemojuvelin, a key protein in systemic iron metabolism, to BMP-2 and neogenin.Semantic proximity Read ↗

Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overloadSemantic proximity Read ↗

Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis.Semantic proximity Read ↗

The molecular mechanism of hepcidin-mediated ferroportin down-regulation.Semantic proximity Read ↗

Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6.Semantic proximity Read ↗

Complex biosynthesis of the muscle-enriched iron regulator RGMc.Semantic proximity Read ↗

Role of matriptase-2 (TMPRSS6) in iron metabolism.Semantic proximity Read ↗

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