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Article

Complex biosynthesis of the muscle-enriched iron regulator RGMc.

Journal of cell science - 15 Aug 2006

Kuninger David, Kuns-Hashimoto Robin, Kuzmickas Ryan, Rotwein Peter

Abstract excerpt

The recently discovered repulsive guidance molecule c (RGMc or hemojuvelin) gene encodes a putative glycosylphosphatidylinositol (GPI)-anchored protein that is expressed in striated muscle and in liver. Mutations in this gene have been linked to the severe iron storage disease, juvenile hemochromatosis, although the mechanisms of action of RGMc in iron metabolism are unknown. As a first step toward understanding...

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Identifiers

PMID: 16868025
DOI: 10.1242/jcs.03074

Genes

GPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Complex biosynthesis of the muscle-enriched iron regulator RGMc.PMID 16868025Read ↗

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