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Article

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression.

Nature genetics - 1 May 2006

Babitt Jodie L, Huang Franklin W, Wrighting Diedra M, Xia Yin, Sidis Yisrael, Samad Tarek A, Campagna Jason A, Chung Raymond T, Schneyer Alan L, Woolf Clifford J, Andrews Nancy C, Lin Herbert Y

Abstract excerpt

Hepcidin is a key regulator of systemic iron homeostasis. Hepcidin deficiency induces iron overload, whereas hepcidin excess induces anemia. Mutations in the gene encoding hemojuvelin (HFE2, also known as HJV) cause severe iron overload and correlate with low hepcidin levels, suggesting that hemojuvelin positively regulates hepcidin expression. Hemojuvelin is a member of the repulsive guidance molecule (RGM)...

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Source

Identifiers

PMID: 16604073
DOI: 10.1038/ng1777

Genes

HJV
RGMA
RGMB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression.PMID 16604073Read ↗

Soluble repulsive guidance molecule c/hemojuvelin is a broad spectrum bone morphogenetic protein (BMP) antagonist and inhibits both BMP2- and BMP6-mediated signaling and gene expression.Semantic proximity Read ↗

Bone morphogenetic proteins as regulators of iron metabolism.Semantic proximity Read ↗

Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6.Semantic proximity Read ↗

Selective binding of RGMc/hemojuvelin, a key protein in systemic iron metabolism, to BMP-2 and neogenin.Semantic proximity Read ↗

Matriptase-2- and proprotein convertase-cleaved forms of hemojuvelin have different roles in the down-regulation of hepcidin expression.Semantic proximity Read ↗

Neogenin Facilitates the Induction of Hepcidin Expression by Hemojuvelin in the Liver.Semantic proximity Read ↗

Defective Bone Morphogenic Protein Signaling Underlies Hepcidin Deficiency in HFE Hereditary HemochromatosisSemantic proximity Read ↗

Neogenin-mediated hemojuvelin shedding occurs after hemojuvelin traffics to the plasma membrane.Semantic proximity Read ↗

Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsivenessSemantic proximity Read ↗

Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overloadSemantic proximity Read ↗

The Molecular Pathogenesis of Hereditary HemochromatosisSemantic proximity Read ↗

Repulsive guidance molecules (RGMs) and neogenin in bone morphogenetic protein (BMP) signalingSemantic proximity Read ↗

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