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Article

Selective binding of RGMc/hemojuvelin, a key protein in systemic iron metabolism, to BMP-2 and neogenin.

American journal of physiology. Cell physiology - 1 Apr 2008

Kuns-Hashimoto Robin, Kuninger David, Nili Mahta, Rotwein Peter

Abstract excerpt

Juvenile hemochromatosis is a severe and rapidly progressing hereditary disorder of iron overload, and it is caused primarily by defects in the gene encoding repulsive guidance molecule c/hemojuvelin (RGMc/HJV), a recently identified protein that undergoes a complicated biosynthetic pathway in mu...

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Source

Identifiers

PMID: 18287331
DOI: 10.1152/ajpcell.00563.2007

Genes

HJV

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18287331-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Selective binding of RGMc/hemojuvelin, a key protein in systemic iron metabolism, to BMP-2 and neogenin.PMID 18287331Read ↗

Soluble repulsive guidance molecule c/hemojuvelin is a broad spectrum bone morphogenetic protein (BMP) antagonist and inhibits both BMP2- and BMP6-mediated signaling and gene expression.Semantic proximity Read ↗

Pro-protein convertases control the maturation and processing of the iron-regulatory protein, RGMc/hemojuvelin.Semantic proximity Read ↗

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression.Semantic proximity Read ↗

Complex biosynthesis of the muscle-enriched iron regulator RGMc.Semantic proximity Read ↗

Hemojuvelin N-terminal mutants reach the plasma membrane but do not activate the hepcidin response.Semantic proximity Read ↗

Structure of the repulsive guidance molecule (RGM)-neogenin signaling hub.Semantic proximity Read ↗

Repulsive guidance molecules (RGMs) and neogenin in bone morphogenetic protein (BMP) signalingSemantic proximity Read ↗

The Capillary Morphogenesis Gene 2 Triggers the Intracellular Hallmarks of Collagen VI-Related Muscular Dystrophy.Semantic proximity Read ↗

Neogenin Facilitates the Induction of Hepcidin Expression by Hemojuvelin in the Liver.Semantic proximity Read ↗

Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overloadSemantic proximity Read ↗

Neogenin-mediated hemojuvelin shedding occurs after hemojuvelin traffics to the plasma membrane.Semantic proximity Read ↗

Defective targeting of hemojuvelin to plasma membrane is a common pathogenetic mechanism in juvenile hemochromatosisSemantic proximity Read ↗

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