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Article

COMT polymorphisms and anxiety-related personality traits.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Nov 2005

Stein Murray B, Fallin Margaret Daniele, Schork Nicholas J, Gelernter Joel

Abstract excerpt

High neuroticism and low extraversion are characteristic of anxiety-prone individuals. A functional variant in the catechol-O-methyltransferase (COMT) gene, the Val158Met ('val/met') polymorphism, has been associated in some prior studies with several phenotypes, including neuroticism. We tested the hypothesis that the val158met polymorphism would be associated with both high neuroticism and low extraversion,...

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Source

Identifiers

PMID: 15956988
DOI: 10.1038/sj.npp.1300787

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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