Article
Frequent splicing aberration of the base excision repair gene hMYH in human gastric cancer.
Anticancer research - 1 Jan 2000
Kobayashi Katsutoshi, Shida Atsuo, Yamada Hisashi, Ishibashi Yoshio, Nakayama Ritsuko, Toriumi Yasuo, Mitsumori Norio, Kashiwagi Hideyuki, Yanaga Katsuhiko
Abstract excerpt
BACKGROUND: Missense mutation of hMYH, which prevents transversion mutations induced by oxidative DNA damage, is reportedly associated with the development of gastric and colon cancer. We investigated whether deficiency or mutation of hMYH is associated with gastric carcinogenesis. PATIENTS AND METHODS: Thirty patients with gastric carcinoma, three gastric cancer cell lines and lymphocytes from three healthy...
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