Article
Transcripts with splicings of exons 15 and 16 of the hMLH1 gene in normal lymphocytes: implications in RNA-based mutation screening of hereditary non-polyposis colorectal cancer.
European journal of cancer (Oxford, England : 1990) - 1 May 1998
Palmirotta R, Verì M C, Curia M C, Aceto G, D'Amico F, Esposito D L, Arcuri P, Mariani-Costantini R, Messerini L, Mori S, Cama A, Battista P
Abstract excerpt
Germline mutations of the hMLH1 gene are estimated to account for a large fraction of kindreds affected by hereditary non-polyposis colorectal cancer (HNPCC). In a significant number of cases, hMLH1 mutations result in the expression of truncated proteins. We report here two novel alternatively spliced forms of hMLH1 mRNA in normal lymphocytes. One of these novel isoforms lacks the coding region of the gene...
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