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Article

A single nucleotide polymorphism at the splice donor site of the human MYH base excision repair genes results in reduced translation efficiency of its transcripts.

Genes to cells : devoted to molecular & cellular mechanisms - 1 May 2002

Yamaguchi Satoru, Shinmura Kazuya, Saitoh Takayuki, Takenoshita Seiichi, Kuwano Hiroyuki, Yokota Jun

Abstract excerpt

BACKGROUND: Adenine paired with 8-hydroxyguanine, a major oxidatively damaged DNA lesion, is excised by mutY homologue (MYH) base excision repair protein in human cells. Since genetic polymorphisms of DNA repair genes associated with the activities and the expression levels of their products may modulate cancer susceptibility of individuals, we investigated the effect of a single nucleotide polymorphism (SNP) in...

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PMID: 12056405
DOI: 10.1046/j.1365-2443.2002.00532.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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