Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aberrant RNA splicing in the hMSH2 gene: molecular identification of three aberrant RNA in Scottish patients with colorectal cancer in the West of Scotland.

American journal of medical genetics - 6 Nov 2000

Davoodi-Semiromi A, Lanyon G W, Davidson R, Connor M J

Abstract excerpt

Blood samples from 47 unselected patients with colorectal cancer were used as a source of hMSH2 mRNA. We identified three new hMSH2 aberrant mRNAs including: 1) IVS15 +5 G-->C resulting in exon 15 skipping from transcript; 2) an mRNA deletion of exons 2 to 6 inclusive; and 3) an mRNA deletion of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal Neoplasms, Hereditary Nonpolyposis
Share to DNA, Complementary
Share to Family Health

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MutS Homolog 2 Protein

Share to Proto-Oncogene Proteins

Share to RNA Splicing

Share to Scotland

Share to Sequence Deletion

Source

Identifiers

PMID: 11074494
DOI: 10.1002/1096-8628(20001106)95:1<49::aid-ajmg10>3.0.co;2-p

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11074494-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Aberrant RNA splicing in the hMSH2 gene: molecular identification of three aberrant RNA in Scottish patients with colorectal cancer in the West of Scotland.PMID 11074494Read ↗

Naturally occurring splicing variants of the hMSH2 gene containing nonsense codons identify possible mRNA instability motifs within the gene coding region.Semantic proximity Read ↗

A truncated hMSH2 transcript occurs as a common variant in the population: implications for genetic diagnosis.Semantic proximity Read ↗

Intron splice acceptor site sequence variation in the hereditary non-polyposis colorectal cancer gene hMSH2.Semantic proximity Read ↗

RNA-based mutation screening in hereditary nonpolyposis colorectal cancer.Semantic proximity Read ↗

Pathogenicity of missense and splice site mutations in hMSH2 and hMLH1 mismatch repair genes: implications for genetic testing.Semantic proximity Read ↗

Transcripts with splicings of exons 15 and 16 of the hMLH1 gene in normal lymphocytes: implications in RNA-based mutation screening of hereditary non-polyposis colorectal cancer.Semantic proximity Read ↗

Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability.Semantic proximity Read ↗

Systematic mRNA analysis for the effect of MLH1 and MSH2 missense and silent mutations on aberrant splicing.Semantic proximity Read ↗

Reduction in hMSH2 mRNA levels by premature translation termination: implications for mutation screening in hereditary nonpolyposis colorectal cancer.Semantic proximity Read ↗

Frequent splicing aberration of the base excision repair gene hMYH in human gastric cancer.Semantic proximity Read ↗

Mutation of the hMSH2 gene in two families with hereditary nonpolyposis colorectal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.