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Article

Th17 development and autoimmune arthritis in the absence of reactive oxygen species.

European journal of immunology - 1 Apr 2008

George-Chandy Annie, Nordström Inger, Nygren Erik, Jonsson Ing-Marie, Postigo Jorge, Collins Laurence Vincent, Eriksson Kristina

Abstract excerpt

Dendritic cells (DC) express a functional NADPH oxidase and produce reactive oxygen species (ROS) upon interaction with microbes and T cells. Exposure to ROS leads to DC activation and maturation, as evidenced by phenotypic and functional changes. We have evaluated how endogenous ROS production affects the cytokine secretion pattern and T cell-activating capacity of bone marrow-derived murine DC. DC treated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18383034
DOI: 10.1002/eji.200737348

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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