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Article

Deficient production of reactive oxygen species leads to severe chronic DSS-induced colitis in Ncf1/p47phox-mutant mice.

PloS one - 1 Jan 2014

Rodrigues-Sousa Tiago, Ladeirinha Ana Filipa, Santiago Ana Raquel, Carvalheiro Helena, Raposo Bruno, Alarcão Ana, Cabrita António, Holmdahl Rikard, Carvalho Lina, Souto-Carneiro M Margarida

Abstract excerpt

BACKGROUND: Colitis is a common clinical complication in chronic granulomatous disease (CGD), a primary immunodeficiency caused by impaired oxidative burst. Existing experimental data from NADPH-oxidase knockout mice propose contradictory roles for the involvement of reactive oxygen species in colitis chronicity and severity. Since genetically controlled mice with a point-mutation in the Ncf1 gene are susceptible...

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Identifiers

PMID: 24873968
DOI: 10.1371/journal.pone.0097532
PMCID: PMC4038546

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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