Article
Mice producing less reactive oxygen species are relatively resistant to collagen glycopeptide vaccination against arthritis.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2010
Batsalova Tsvetelina, Dzhambazov Balik, Klaczkowska Dorota, Holmdahl Rikard
Abstract excerpt
The bottleneck for the induction of collagen-induced arthritis in mice is the recognition of immunodominant type II collagen (CII) peptide (CII259-273) bound to the MHC class II molecule A(q). We have shown previously that the posttranslationally glycosylated lysine at position 264 in this epitope is of great importance for T cell recognition and tolerance induction to CII as well as for arthritis development....
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