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Article

Bimolecular Fluorescence Complementation of Alpha-synuclein Demonstrates its Oligomerization with Dopaminergic Phenotype in Mice.

EBioMedicine - 1 Mar 2018

Cai Waijiao, Feng Danielle, Schwarzschild Michael A, McLean Pamela J, Chen Xiqun

Abstract excerpt

Alpha-synuclein (αSyn) is encoded by the first causal gene identified in Parkinson's disease (PD) and is the main component of Lewy bodies, a pathological hallmark of PD. aSyn-based animal models have contributed to our understanding of PD pathophysiology and to the development of therapeutics. Overexpression of human wildtype αSyn by viral vectors in rodents recapitulates the loss of dopaminergic neurons from...

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Identifiers

PMID: 29433982
DOI: 10.1016/j.ebiom.2018.01.035
PMCID: PMC5925445

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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