Article
Amino acid similarity accounts for T cell cross-reactivity and for "holes" in the T cell repertoire.
PloS one - 19 Mar 2008
Frankild Sune, de Boer Rob J, Lund Ole, Nielsen Morten, Kesmir Can
Abstract excerpt
BACKGROUND: Cytotoxic T cell (CTL) cross-reactivity is believed to play a pivotal role in generating immune responses but the extent and mechanisms of CTL cross-reactivity remain largely unknown. Several studies suggest that CTL clones can recognize highly diverse peptides, some sharing no obvious sequence identity. The emerging realization in the field is that T cell receptors (TcR) recognize multiple distinct...
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