HLA Class I Supertype Classification Based on Structural Similarity.

Abstract excerpt

HLA class I proteins, a critical component in adaptive immunity, bind and present intracellular Ags to CD8+ T cells. The extreme polymorphism of HLA genes and associated peptide binding specificities leads to challenges in various endeavors, including neoantigen vaccine development, disease association studies, and HLA typing. Supertype classification, defined by clustering functionally similar HLA alleles, has...

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• Share to Alleles
• Share to CD8-Positive T-Lymphocytes
• Share to Peptides