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Article

Caspase polymorphisms and genetic susceptibility to multiple myeloma.

Hematological oncology - 1 Sept 2008

Hosgood H Dean, Baris Dalsu, Zhang Yawei, Zhu Yong, Zheng Tongzhang, Yeager Meredith, Welch Robert, Zahm Shelia, Chanock Stephen, Rothman Nathaniel, Lan Qing

Abstract excerpt

Multiple myeloma is a haematological malignency, characterized by clonal expansion of plasma cells. However, little is known about the cause of multiple myeloma. Cancer cells must avoid apoptosis to ensure unregulated tumour formation and growth. The highly conserved caspase cascade is essential to the regulation of the apoptotic pathway. To examine if five single nucleotide polymorphisms (SNPs) in four caspase...

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Source

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Identifiers

PMID: 18381704
DOI: 10.1002/hon.852
PMCID: PMC2586415

Genes

CASP3
CASP9
CASP10
CASP8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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