Article
Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk.
Nature genetics - 27 Nov 2011
Broderick Peter, Chubb Daniel, Johnson David C, Weinhold Niels, Försti Asta, Lloyd Amy, Olver Bianca, Ma Yussanne, Dobbins Sara E, Walker Brian A, Davies Faith E, Gregory Walter A, Childs J Anthony, Ross Fiona M, Jackson Graham H, Neben Kai, Jauch Anna, Hoffmann Per, Mühleisen Thomas W, Nöthen Markus M, Moebus Susanne, Tomlinson Ian P, Goldschmidt Hartmut, Hemminki Kari, Morgan Gareth J, Houlston Richard S
Abstract excerpt
To identify risk variants for multiple myeloma, we conducted a genome-wide association study of 1,675 individuals with multiple myeloma and 5,903 control subjects. We identified risk loci for multiple myeloma at 3p22.1 (rs1052501 in ULK4; odds ratio (OR) = 1.32; P = 7.47 × 10(-9)) and 7p15.3 (rs4487645, OR = 1.38; P = 3.33 × 10(-15)). In addition, we observed a promising association at 2p23.3 (rs6746082, OR =...
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