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Article

GLI1 is a central mediator of EWS/FLI1 signaling in Ewing tumors.

PloS one - 27 Oct 2009

Joo Jay, Christensen Laura, Warner Kegan, States Leith, Kang Hyung-Gyoo, Vo Kieuhoa, Lawlor Elizabeth R, May William A

Abstract excerpt

The Ewing Sarcoma Family Tumors (ESFT) consist of the classical pathologic entities of Ewing Sarcoma and peripheral Primitive Neuroectodermal Tumor. Occurring largely in the childhood through young adult years, these tumors have an unsurpassed propensity for metastasis and have no defined cell of origin. The biology of these aggressive malignancies centers around EWS/FLI1 and related EWS/ETS chimeric...

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Topics

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Share to Gene Expression Regulation, Neoplastic
Share to Oncogene Proteins, Fusion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proto-Oncogene Protein c-fli-1

Share to Retroviridae

Share to RNA-Binding Protein EWS

Share to RNA Interference

Share to Sarcoma, Ewing

Share to Zinc Finger Protein GLI1

Source

Open in PubMed Open full text

Identifiers

PMID: 19859563
DOI: 10.1371/journal.pone.0007608
PMCID: PMC2763206

Genes

FLI1
GLI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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