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High p16INK4A expression in glioblastoma is associated with senescence phenotype and better prognosis

25 Dec 2024

Abstract excerpt

Glioblastoma, isocitrate dehydrogenase (IDH)-wildtype (GBM), is the most malignant brain tumor in adults, with limited therapeutic intervention. Previous studies have identified a few prognostic markers for GBM, including the methylation status of O 6 -methylguanine-DNA methyltransferase ( MGMT ) promoter, TERT promoter mutation, EGFR amplification, and CDKN2A/2B deletion. However, the classification of GBM...

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PMID: 39724755
DOI: 10.1016/j.neo.2024.101116

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