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Article

Feedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development

1 Apr 2008

Abstract excerpt

We have developed a nonheuristic genome topography scan (GTS) algorithm to characterize the patterns of genomic alterations in human glioblastoma (GBM), identifying frequent p18(INK4C) and p16(INK4A) codeletion. Functional reconstitution of p18(INK4C) in GBM cells null for both p16(INK4A) and p18(INK4C) resulted in impaired cell-cycle progression and tumorigenic potential. Conversely, RNAi-mediated depletion of...

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PMID: 18394558
DOI: 10.1016/j.ccr.2008.02.010

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