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Article

Protective effects of interrupting the binding of calmodulin to mutant huntingtin.

Journal of neuropathology and experimental neurology - 1 Apr 2008

Dudek Nichole L, Dai Ying, Muma Nancy A

Abstract excerpt

There is evidence suggesting that transglutaminase (TG) 2 plays a role in stabilizing monomeric and aggregated huntingtin, thereby contributing to the pathophysiology of Huntington disease. Calmodulin (CaM) regulates TG2 cross-linking of N-terminal mutant huntingtin in cells and colocalizes with TG and huntingtin in inclusions in Huntington disease cortex. The current study examined the effects of small fragments...

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Source

Identifiers

PMID: 18379433
DOI: 10.1097/NEN.0b013e31816a9e60

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Protective effects of interrupting the binding of calmodulin to mutant huntingtin.PMID 18379433Read ↗

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